Table 1.
Necropsy data
| Control (n = 12) | PI-IUGR (n = 10) | Change, % | P Value | |
|---|---|---|---|---|
| Necropsy data | ||||
| Fetal wt, g | 3,391.4 ± 228.0 | 2,044.0 ± 163.8 | ↓40% | <0.001 |
| Placental wt, g | 324.8 ± 34.6 | 218.9 ± 17.8 | ↓33% | 0.03* |
| Age at Necropsy, days | 134 ± 1 | 133 ± 1 | 0.7 | |
| Crown to rump length, mm | 468 ± 13 | 403 ± 9 | ↓14% | <0.001 |
| Sex | ||||
| Female n (%) | 4 (33%) | 4 (45%) | ||
| Male n (%) | 8 (67%) | 6 (55%) | ||
| Morphology | ||||
| Thoracic | ||||
| ID, mm | 3.98 ± 0.23 | 3.52 ± 0.16 | 0.21 | |
| Thickness, mm | 1.99 ± 0.07 | 1.38 ± 0.08 | ↓30% | <0.001 |
| ID-to-thickness ratio | 1.93 ± 0.14 | 2.61 ± 0.19 | ↑35% | 0.008 |
| Cross-sectional area, mm2 | 37.6 ± 2.2 | 21.6 ± 2.1 | ↓43% | <0.001 |
| Abdominal | ||||
| ID, mm | 4.58 ± 0.81 | 3.75 ± 0.16 | ↓18% | 0.01 |
| Thickness, mm | 0.67 ± 0.13 | 0.54 ± 0.09 | ↓19% | 0.02 |
| ID-to-thickness ratio | 7.08 ± 0.63 | 7.12 ± 0.64 | 0.96 | |
| Cross-sectional area, mm2 | 11.1 ± 2.8 | 7.3 ± 1.3 | ↓34% | <0.01 |
| Biochemical composition | ||||
| Thoracic | ||||
| Hydroxyproline, μg/mg dry tissue | 54.0 ± 3.3 | 66.8 ± 2.9 | ↑24% | 0.01 |
| Desmosine, μg/mg dry tissue | 3.00 ± 0.39 | 3.90 ± 0.15 | ↑30% | 0.05 |
| sGAG, μg/mg dry tissue | 32.9 ± 1.7 | 21.9 ± 1.3 | ↓33% | <0.001 |
| Abdominal | ||||
| Hydroxyproline, μg/mg dry tissue | 78.0 ± 6.0 | 101.4 ± 6.0 | ↑30% | 0.010 |
| Desmosine, μg/mg dry tissue | 2.80 ± 0.31 | 2.94 ± 0.39 | 0.78 | |
| sGAG, μg/mg dry tissue | 28.4 ± 2.1 | 17.5 ± 1.1 | ↓38% | <0.001 |
Values are means ± SE; n, no. of ewes. ID, inner diameter; sGAG, sulfated glycosaminoglycans; ↓, decrease; ↑, increase. Animals show reduced fetal size in the placental insufficiency intrauterine growth restriction (PI-IUGR) model. PI-IUGR vessels have reduced geometry and remodeled wall composition.
*
Mann-Whitney Nonparametric test.