Fig. 1.

Resveratrol (RSV) treatment rescues neurovascular coupling in aged mice. A: representative traces of cerebral blood flow (CBF) measured with a laser Doppler probe above the whisker barrel cortex during contralateral whisker stimulation (1 min, 10 Hz) in young (3 mo old), aged (24 mo old), and resveratrol-treated aged mice[0.1 arbitrary units (AU) corresponds to ∼5% increase in CBF from baseline]. B: summary data of the effect of resveratrol treatment (200 mg/kg, 10 days in food) on CBF responses to whisker stimulation and on baseline CBF (C) in young and aged mice. Data are means ± SE (n = 8 in each group). *P < 0.05 vs. young; ^#P < 0.05 vs. aged.