Fig. 2.

Resveratrol treatment rescues nitric oxide (NO) mediation of neurovascular coupling in aged mice. A: changes of CBF in response to whisker-stimulation in the absence and presence of the NO synthase inhibitor N^ω-nitro-l-arginine methyl ester (l-NAME) above the barrel cortex in control and resveratrol-treated young (3 mo old) and aged (24 mo old) mice. B: l-NAME-sensitive component of CBF responses to whisker stimulation. Data are means ± SE (n = 7–8 in each group). *P < 0.05 vs. young; ^#P < 0.05 vs. aged; ^&P < 0.05 vs. aged + resveratrol.