Fig. 3.

Resveratrol treatment rescues acetylcholine-induced, endothelial NO-mediated CBF responses in aged mice. Changes of CBF are shown in response to the endothelium-dependent dilator acethylcholine (A) and the endothelium-independent dilator adenosine (C) in the absence and presence of the NO synthase inhibitor l-NAME above the barrel cortex in control and resveratrol-treated young (3 mo old) and aged (24 mo old) mice. B: l-NAME-sensitive component of acetylcholine-induced CBF responses. Data are means ± SE (n = 7–8 in each group). *P < 0.05 vs. young; ^#P < 0.05 vs. aged; ^&P < 0.05 vs. aged + resveratrol.