Fig. 4.

Resveratrol treatment attenuates oxidative stress in aged mice. A: administration of the NADPH oxidase inhibitor apocynin improves CBF responses elicited by whisker-stimulation in aged (24 mo old) mice. CBF responses in young (3 mo old) mice are shown for comparison. Data are means ± SE (n = 6 in each group) *P < 0.05 vs. young; ^#P < 0.05 vs. aged control. B: cortical 3-nitrotyrosine content and 8-isoprostane level (C) in young, resveratrol-treated young, aged, and resveratrol-treated aged mice (n = 6 in each group). Data are means ± SE. *P < 0.05 vs. young control; ^#P < 0.05 vs. aged control.