Table 1.
Pre- and Postantibody Comparisons of Isolated Heart Size, Compliance, Coronary Flow, and Contractility
| Anti-β1-Integrin Bolus |
Anti-β3-Integrin Bolus |
Preimmunized IgG Bolus |
||||
|---|---|---|---|---|---|---|
| Prebolus | Postbolus | Prebolus | Postbolus | Prebolus | Postbolus | |
| V0, μl | 257.7 ± 15.5 | 293.6 ± 19.8* | 214.4 ± 18.4 | 219.1 ± 18.5 | 199.1 ± 24.8 | 200.1 ± 24.9 |
| ΔV0–25, μl | 65.9 ± 13.4 | 63.4 ± 12.5 | 132.9 ± 24.3 | 123.0 ± 23.3 | 138.8 ± 42.2 | 131.6 ± 38.0 |
| Pmax-V slope, mmHg/μl | 0.89 ± 0.25 | 0.80 ± 0.20 | 0.63 ± 0.14 | 0.71 ± 0.14 | 0.75 ± 0.20 | 0.69 ± 0.14 |
| Coronary flow, ml/min | 2.0 ± 1.0 | 3.9 ± 2.4* | 3.5 ± 1.9 | 5.3 ± 2.8* | 4.0 ± 2.0 | 4.6 ± 2.4 |
Values are means ± SE. Cardiac dimension and functional parameters obtained from isolated heart preparation for the left ventricular (LV) volume at an end-diastolic pressure (EDP) of 0 mmHg (V0); the amount of volume required to increase EDP from 0 to 25 mmHg (V0–25); the slope of the linear peak isovolumetric pressure-volume relationship (Pmax-V), which serves as an assessment of intrinsic LV contractility; and coronary flow are shown.
*
P < 0.05 vs. prebolus.