Fig 2.

The process of Pancreatic βcell tumor in Rip1-Tag2 transgenic mice. A. Normal stage, the Islet cell is normal and same as C57BL/6 mice(Fig 2A); B. Hyperplastic islet stage, dysplastic begin to appear, most of cell nuclear/cytoplasm ratio increases(Fig 2B), C. Angiogenic islets stage, angiogenic Islets began to appear(Fig 2C), D. Tumor stage, the vascular network is highly developed, solid tumors formed(Fig 3D). E. Invasion stage. Tumor infiltrate into the surrounding acinar tissue (Fig 2E and 2F).