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. 2014 Jan 20;10(2):171–180. doi: 10.7150/ijbs.7357

Figure 6.

Figure 6

Inhibition of FASN decreased expressions of L-FABP, VEGF, and VEGFR-2 in both in vitro and in vivo models. A. RT-PCR result assay showed decreases of FASN, L-FABP, VEGF, and VEGFR-2 mRNAs in MCF-7-MEK5 cells. B. Quantitative real-time PCR assay showed that Cerulenin treatment significantly decreased levels of FASN, L-FABP, VEGF, and VEGFR-2 in MCF-7-MEK5 cells. In nude mouse tumor tissues (in vivo model), Cerulenin treatment also decreased levels of FASN, L-FABP, VEGF, and VEGFR-2. C. WB result showed that proteins of FASN, L-FABP, VEGF, and VEGFR-2 were downregulated in MCF-7-MEK5 cells after Cerulenin treatment.