Fig. 6.

Effect of ROCK inhibition on PPARγ activity and proliferation in normal and PPHN PASMC. At baseline PPARγ activity was decreased in PPHN PASMCs and increased with ROCK inhibition [y-27632 (5 mM)], restoring PPARγ activity to normal values (A). For all figures representative blots are shown. ROCK inhibition decreased growth of PPHN PASMC (B) and restored proliferation of PPHN PASMC to similar values seen in normal untreated controls. PPARγ activity and growth in normal PASMC was unchanged in response to ROCK inhibition.