Fig. 10.

Expression of lysyl hydroxylases in human neonates with normal lung development or in neonates afflicted with, or at risk for, bronchopulmonary dysplasia (BPD). PLOD1 (A), PLOD2 (B), and PLOD3 (C) expression was assessed by real-time RT-PCR using the primers listed in Table 1, in mRNA pools from patients afflicted with or at risk for BPD (Table 2), from control patients matched to the BPD group for gestational age at birth (GAB; Table 3), or from control patients matched to the BPD group for chronological age at death (CAD; Table 3). The HPRT gene was used as a reference. The bars represent the data range, the boxes represent the lower and upper quartiles, and the line within the quartile box indicates the median. No outliers were noted by Grubbs' test. The P values represented compare the 3 patient groups and were assessed by 1-way analysis of variance with the Newman-Keuls post hoc test (see Tables 2 and 3 for number of patients per group).