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. 2013 Nov 15;306(2):L120–L131. doi: 10.1152/ajplung.00240.2013

Fig. 6.

Fig. 6.

Temporal changes in cytokine/chemokine expression following TSG-6 treatment in the bleomycin model of lung injury. TSG-6 (50 μg) treatment significantly decreased TNF-α (A) expression on both days 2 and 3, whereas decreasing IL-6 (B) only on day 3 in comparison with PBS-treated mice. Surprisingly, TSG-6 initially increased IL-1β (C) expression on day 2 but decreased it significantly by day 8. TSG-6 treatment significantly increased expression of CCL2/MCP-1 (D), CCL3/MIP-1α (E), and CXCL2/MIP-2 (G) chemokines on day 2, whereas significantly increasing CXCL1/KC (F) on both days 2 and 4. No significant differences in protein concentration (H) were observed after TSG-6 treatment. Values are represented as arithmetic means ± SE (n = 5–8 mice per group). P values were calculated by 1-way ANOVA with a post hoc Bonferroni's multiple comparison analysis performed between all the groups. Only significant differences between bleomycin-injured (PBS and TSG-6) groups are indicated in the figure: *P < 0.05, **P < 0.01, and ***P < 0.001.