Fig. 9.

Temporal changes in cytokine/chemokine expression following TSG-6 treatment in CD44 knockout mice. No significant changes were observed in CD44 knockout mice after TSG-6 (50 μg) treatment in any of the proinflammatory cytokines examined such as IL-6 (A), TNF-α (B), and IL-1β (C), or in the expression of chemokines such as CCL2/MCP-1 (D), CCL3/MIP-1α (E), and CXCL2/MIP-2 (G), or in protein concentration (H) levels. However, TSG-6 treatment significantly decreased CXCL1/KC (F) levels only on day 5 compared with the PBS group. Values are represented as arithmetic means ± SE (n = 5–8 mice per group). P values were calculated by 1-way ANOVA with a post hoc Bonferroni's multiple comparison analysis performed between all the groups. No P values are indicated on this figure since there were no statistical differences between the bleomycin-injured (PBS and TSG-6) groups in most of the cytokines/chemokines tested and at any of the time points examined.