Fig. 1.
The synergistic effects of IL-17 and TNF-α on lung dysfunction after ischemia-reperfusion (I/R) are mediated by NADPH oxidase. Lung function was measured in wild-type (WT) and p47phox−/− mice after I/R or sham surgery. A significant increase in airway resistance and pulmonary artery pressure as well as a decrease in pulmonary compliance occurred in WT mice after I/R vs. sham, which was further exacerbated by combined treatment with IL-17 and TNF-α (TNF). Pulmonary dysfunction after I/R was significantly attenuated in p47phox−/− mice (p47−/−) vs. WT mice. Combined treatment with IL-17 and TNF-α failed to induce any significant change in lung function in p47phox−/− mice after I/R. *P < 0.05 vs. WT sham; **P < 0.05 vs. all; #P < 0.05 vs. WT I/R; n = 6–8 mice/group.