Table 2.
Maximum uterine artery relaxation responses (percent relaxation from submaximal responses to phenylephrine) to various agonists in Wistar and GK nonpregnant and pregnant rats
Wistar |
GK |
|||
---|---|---|---|---|
Nonpregnant | Pregnant | Nonpregnant | Pregnant | |
ACh | 87.2 ± 3.56 | 80.2 ± 4.71 | 74.7 ± 6.24 | 84.3 ± 4.10 |
Sodium nitroprusside | 92.3 ± 1.31 | 69.7 ± 7.82a,b | 81.8 ± 2.61 | 88.3 ± 2.81 |
NONOate | 97.5 ± 1.27 | 90.3 ± 2.73a | 97.4 ± 0.76 | 96.1 ± 1.67 |
8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt | 66.6 ± 6.07 | 66.5 ± 7.92 | 65.9 ± 11.73 | 71.9 ± 3.02 |
Sildenafil | 85.1 ± 5.91c | 46.7 ± 4.18a | 53.1 ± 6.05 | 44.8 ± 5.63 |
Values are means ± SE; n = 8–10 for Wistar nonpregnant, n = 4–9 for Wistar pregnant, n = 4–10 for GK nonpregnant, and n = 4–9 for GK pregnant.
P < 0.05: Wistar nonpregnant vs. Wistar pregnant;
P < 0.05: Wistar pregnant vs. GK pregnant;
P < 0.05: Wistar nonpregnant vs. GK nonpregnant.