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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Epilepsia. 2013 Jan 7;54(3):471–480. doi: 10.1111/epi.12062

Figure 1.

Figure 1

Spike-related activation (red) and deactivation (blue), controlling for number of spikes, are overlayed on the standard MNI anatomic brain in radiologic orientation. Spike times obtained from a simultaneous EEG recording were convolved with a canonical gamma variate hemodynamic response function (HRF)with its peak 4.7 s post onset using AFNI. Activation maps were produced with HRF onset aligied with spikes (0 s), before spikes (−1,−2, … s), and after spikes (+1,+2, … s). Group responses from all subjects (left) and a contrast between vdproate (VPA)-resistant and VPA-responsive subjects(right) were obtained. Significant (a < 0.05) clusters of >36 suprathreshold voxels (left: two-sided t > 2.3, right: one-sided t > 2) are shown.

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