Figure 1.

Musculoskeletal sensitization enhances bilateral responses to von Frey testing. Mice injected with acidified saline (n = 16) exhibit mechanical hypersensitivity for at least 21 days, whereas mechanical hypersensitivity does not develop in mice injected with normal pH saline (n = 14). Responsiveness to von Frey filaments are plotted as mean ± SEM total response incidence percent ([total responses / total filament presentations] × 100) per paw. *P ≤ 0.05 vs. normal pH saline injection.