Table 1.
Patient A | Patient B | Patient C | |
---|---|---|---|
Age at diagnosis IPFa/Ltxb | 46/48 years | 53/57 years | 47/53 years |
Histologic confirmation IPF | yes, UIPc | yes, UIP | yes, UIP |
Smoking status | ex, 30 packyears | ex, 26 packyears | never |
Treatment IPF (all acetylcysteine/prednisone) | cyclophosfamide | azathioprine | azathioprine |
Singe or bilateral Ltx | single (right) | After rejection single (left) Ltx bilateral Ltx | bilateral |
Histology explanted lung | UIP, no malignancy | left: UIP right: squamous cell carcinoma |
massive bilateral adenocarcinoma with lymphangitis carcinomatosa |
Time Ltx to diagnosis of lung cancer | 8 years, three months | in explanted lung | in explanted lung |
Stage lung cancer | TxNxM1a (stage IV) | T2N2M0 (stage IIIA) | T4N2M1b (stage IV) |
Treatment lung cancer | none, performance too poor | radical chemo-radiotherapy, progression: chemotherapy | palliative radiotherapy symptomatic skeletal metastases, performance too poor for further therapy |
Time diagnosis lung cancer to death | 3 months | 1 year, 10 months | 3 months |
idiopathic pulmonary fibrosis.
lung transplantation
usual interstitial pneumonia.