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. Author manuscript; available in PMC: 2014 Dec 6.
Published in final edited form as: J Org Chem. 2013 Nov 21;78(23):11970–11984. doi: 10.1021/jo4020112

Figure 4.

Figure 4

(−)-Agelastatins A (1) and D (4) both induced dose-dependent apoptosis. Analysis of phosphatidylserine exposure and propidium iodide inclusion at 21 hours in U-937 cells. Compounds were tested at indicated concentrations (four and six times the 48-hour IC50 value) and STS was used as a positive control for apoptosis. Samples were analyzed by flow cytometry for the relative timing of phosphatidylserine exposure relative to PI inclusion. FITC = fluorescein isothiocyanate; PI = propidium iodide; STS = staurosporine.