Table 3.
Summary of main findings of most recent meta-analysis of genome-wide association studies in coronary artery disease, showing the lead single nucleotide polymorphism of each locus, the closest gene, chromosomal location, risk allele and frequency, P-value, and effect size of the reported associations
| rsID | Gene located at or near loci | Chr | Risk/nonrisk allele (risk allele frequency) | Combined P-value | Combined OR |
|---|---|---|---|---|---|
| rs602633 | SORT1 | 1 | C/A (0.77) | 1.47 × 10−25 | 1.12 |
| rs17114036 | PPAP2B | 1 | A/G (0.91) | 5.80 × 10−12 | 1.11 |
| rs4845625 | IL6R | 1 | T/C (0.47) | 3.64 × 10−10 | 1.09 |
| rs67258870 | WDR12 | 2 | C/T (0.11) | 1.16 × 10−15 | 1.12 |
| rs515135 | APOB | 2 | G/A (0.83) | 2.56 × 10−10 | 1.03 |
| rs2252641 | ZEB2-ACO74093 | 2 | G/A (0.46) | 5.30 × 10−8 | 1.06 |
| rs1561198 | VAMP5-VAMP8-GGCX | 2 | A/G (0.45) | 1.22 × 10−10 | 1.07 |
| rs6544713 | ABCG5-ABCG8 | 2 | T/C (0.30) | 2.12 × 10−9 | 0.96 |
| rs9818870 | MRAS | 3 | T/C (0.14) | 2.62 × 10−9 | 1.07 |
| rs7692387 | GUCY1A3 | 4 | G/A (0.81) | 2.65 × 10−11 | 1.13 |
| rs1878406 | EDNRA | 4 | T/C (0.15) | 2.54 × 10−8 | 1.09 |
| rs273909 | SLC22A4-SLC22A5 | 5 | C/T (0.14) | 9.62 × 10−10 | 1.11 |
| rs12190287 | TCF21 | 6 | C/G (0.59) | 4.94 × 10−13 | 1.07 |
| rs2048327 | SLC22A3-LPAL2-LPA | 6 | G/A (0.35) | 6.86 × 10−11 | 1.06 |
| rs9369640 | PHACTR1 | 6 | A/C (0.65) | 7.53 × 10−22 | 1.09 |
| rs10947789 | KCKN5 | 6 | T/C (0.76) | 9.81 × 10−9 | 1.01 |
| rs4252120 | PLG | 6 | T/C (0.73) | 4.88 × 1010 | 1.07 |
| rs11556924 | ZC3HC1 | 7 | C/T (0.65) | 6.74 × 10−17 | 1.09 |
| rs2023938 | HDAC9 | 7 | G/A (0.10) | 4.94 × 10−8 | 1.13 |
| rs264 | LPL | 8 | G/A (0.86) | 2.88 × 10−9 | 1.06 |
| rs2954029 | TRIB1 | 8 | A/T (0.55) | 4.75 × 10−9 | 1.05 |
| rs1333049 | CDKN2BAS1 | 9 | C/G (0.47) | 1.39 × 10−52 | 1.23 |
| rs3217992 | 9 | A/G (0.38) | 7.75 × 10−57 | 1.16 | |
| rs579459 | ABO | 9 | C/T (0.21) | 2.66 × 10−8 | 1.07 |
| rs12413409 | CYP17A1-CNNM2-NT5C2 | 10 | G/A (0.89) | 6.26 × 10−8 | 1.10 |
| rs2505083 | KIAA1462 | 10 | C/T (0.42) | 1.35 × 10−11 | 1.06 |
| rs501120 | CXCL12 | 10 | A/G (0.83) | 1.79 × 10−9 | 1.07 |
| rs2047009 | 10 | C/A (0.48) | 1.59 × 10−9 | 1.05 | |
| rs974819 | PDGFD | 11 | A/G (0.29) | 3.55 × 10−11 | 1.07 |
| rs3184504 | SH2B3 | 12 | T/C (0.40) | 5.44 × 10−11 | 1.07 |
| rs4773144 | COL4A1-COL4A2 | 13 | G/A (0.42) | 1.43 × 10−11 | 1.07 |
| rs9515203 | 13 | T/C (0.74) | 5.85 × 10−12 | 1.08 | |
| rs9319428 | FLT1 | 13 | A/G (0.32) | 7.32 × 10−11 | 1.10 |
| rs2895811 | HHIPL1 | 14 | C/T (0.43) | 4.08 × 10−10 | 1.06 |
| rs7173743 | ADAMTS7 | 15 | T/C (0.58) | 6.74 × 10−13 | 1.07 |
| rs17514846 | FURIN-FES | 15 | A/C (0.44) | 9.33 × 10−11 | 1.04 |
| rs12936587 | RAI1-PEMT-RASD1 | 17 | G/A (0.59) | 1.24 × 10−9 | 1.06 |
| rs2281727 | SMG6 | 17 | C/T (0.36) | 7.83 × 10−9 | 1.05 |
| rs1122608 | LDLR | 19 | G/T (0.76) | 6.33 × 10−14 | 1.10 |
| rs9982601 | Gene desert (KCNE2) | 21 | T/C (0.13) | 7.67 × 10−17 | 1.13 |
Abbreviations: Chr, chromosome; OR, odds ratio.