Table 4.
rsID | Loci | Chr | Risk allele (Risk allele frequency) | Combined P-value | Known effect on CAD | Reference | |
---|---|---|---|---|---|---|---|
Obesity | |||||||
rs2815752 | NEGR1 | 1 | A (0.61) | 1.61 × 10−22 | No | 50 | |
rs543874 | SEC16B | 1 | G (0.19) | 3.56 × 10−23 | No | 50 | |
rs1514175 | TNNI3K | 1 | A (0.43) | 8.16 × 10−14 | No | 50 | |
rs1555543 | PTBP2 | 1 | C (0.59) | 3.68 × 10−10 | No | 50 | |
rs984222 | TBX15-WARS2 | 1 | G (0.64) | 3.81 × 10−14 | No | 49 | |
rs2867125 | TMEM18 | 2 | C (0.83) | 2.77 × 10−49 | No | 50 | |
rs713586 | RBJ | 2 | C (0.47) | 6.17 × 10−22 | No | 50 | |
rs887912 | FANCL | 2 | T (0.29) | 1.79 × 10−12 | No | 50 | |
rs10195252 | GRB14 | 2 | T (0.60) | 2.09 × 10−24 | No | 49 | |
rs13078807 | LRP1B | 2 | C (0.18) | 1.35 × 10−10 | No | 50 | |
rs9816226 | ETV5 | 3 | T (0.82) | 1.69 × 10−18 | No | 50 | |
rs13078807 | CADM2 | 3 | G (0.20) | 3.94 × 10−11 | No | 50 | |
rs6795735 | ADAMTS9 | 3 | C (0.60) | 9.79 × 10−14 | No | 49 | |
rs6784615 | NISCH-STAB1 | 3 | T (0.94) | 3.84 × 10−10 | No | 49 | |
rs13107325 | SLC39A8 | 4 | T (0.07) | 1.50 × 10−13 | No | 50 | |
rs10938397 | GNPDA2 | 4 | G (0.43) | 3.78 × 10−31 | No | 50 | |
rs2112347 | FLJ35779 | 5 | T (0.63) | 2.17 × 10−13 | No | 50 | |
rs4836133 | ZNF608 | 5 | A (0.48) | 1.97 × 10−9 | No | 50 | |
rs681681 | CPEB4 | 5 | A (0.34) | 1.91 × 10−9 | No | 49 | |
rs987237 | TFAP2B | 6 | G (0.18) | 2.90 × 10−20 | No | 50 | |
rs206936 | NUDT3 | 6 | G (0.21) | 3.02 × 10−8 | No | 50 | |
rs9491696 | RSPO3 | 6 | G (0.48) | 1.84 × 10−40 | No | 49 | |
rs6905288 | VEGFA | 6 | A (0.56) | 5.88 × 10−25 | No | 49 | |
rs1294421 | LY86 | 6 | G (0.61) | 1.75 × 10−17 | No | 49 | |
rs1055144 | NFE2L3 | 7 | T (0.21) | 9.97 × 10−18 | No | 49 | |
rs10968576 | LRRN6C | 9 | G (0.31) | 2.65 × 10−13 | No | 50 | |
rs10767664 | BNF | 11 | A (0.78) | 4.69 × 10−26 | No | 50 | |
rs3817334 | MTCH2 | 11 | T (0.40) | 1.59 × 10−12 | No | 50 | |
rs4929949 | RPL27A | 11 | C (0.52) | 2.80 × 10−9 | No | 50 | |
rs7138803 | FAIM2 | 12 | A (0.38) | 1.82 × 10−17 | No | 50 | |
rs718314 | ITPR2-SSPN | 12 | G (0.26) | 1.14 × 10−17 | No | 50 | |
rs1443512 | HOXC13 | 12 | A (0.24) | 6.38 × 10−17 | No | 49 | |
rs4771122 | MTIF3 | 13 | G (0.24) | 9.48 × 10−10 | No | 50 | |
rs10150332 | NRXN3 | 14 | C (0.21) | 2.75 × 10−11 | No | 50 | |
rs11847697 | PRKD1 | 14 | T (0.04) | 5.76 × 10−11 | No | 50 | |
rs2241423 | MAP2K5 | 15 | G (0.78) | 1.19 × 10−18 | No | 50 | |
rs1558902 | FTO | 16 | A (0.42) | 4.8 × 10−120 | No | 50 | |
rs7359397 | SH2B1 | 16 | T (0.40) | 1.88 × 10−20 | No | 50 | |
rs12444979 | GPRC5B | 16 | C (0.87) | 2.91 × 10−21 | No | 50 | |
rs571312 | MC4R | 18 | A (0.24) | 6.43 × 10−42 | No | 50 | |
rs29941 | KCTD15 | 19 | G (0.67) | 3.01 × 10−9 | No | 50 | |
rs2287019 | QPCTL | 19 | C (0.80) | 1.88 × 10−16 | No | 50 | |
rs3810291 | TMEM160 | 19 | A (0.67) | 1.64 × 10−12 | No | 50 | |
rs4823006 | ZNRF3-KREMEN1 | 22 | A (0.57) | 1.10 × 10−11 | No | 49 | |
Diabetes | |||||||
rs340874 | PROX1 | 1 | C (0.52) | 6.6 × 10−12 | No | 47 | |
rs560887 | G6PC2 | 2 | C (0.70) | 8.7 × 10−218 | No | 47 | |
rs780094 | GCKR | 2 | C (0.62) | 5.6 × 10−38 | No | 47 | |
rs243021 | BCL11A | 2 | A (0.46) | 2.9 × 10−15 | No | 52 | |
rs7578326 | IRS1 | 2 | A (0.64) | 5.4 × 10−20 | No | 52 | |
rs11708067 | ADCY5 | 3 | A (0.78) | 7.1 × 10−22 | No | 47 | |
rs11920090 | SLC2A2 | 3 | T (0.87) | 8.1 × 10−13 | No | 47 | |
rs4457053 | ZBED3 | 5 | G (0.26) | 2.8 × 10−12 | No | 52 | |
rs4607517 | GCK | 7 | A (0.16) | 6.5 × 10−92 | No | 47 | |
rs2191349 | DGKB-TMEM195 | 7 | T (0.52) | 3.0 × 10−44 | No | 47 | |
rs972283 | KLF14 | 7 | G (0.55) | 2.2 × 10−10 | No | 52 | |
rs11558471 | SLC30A8 | 8 | A (0.68) | NA | No | 47 | |
rs896854 | TP53INP1 | 8 | T (0.48) | 9.9 × 10−10 | No | 52 | |
rs7034200 | GLIS3 | 9 | A (0.49) | 1.0 × 10−12 | No | 47 | |
rs13292136 | CHCHD9 | 9 | C (0.93) | 2.8 × 10−8 | No | 52 | |
rs10885122 | ADRA2A | 10 | G (0.87) | 2.9 × 10−16 | No | 47 | |
rs4506565 | TCF7L2 | 10 | T (0.31) | NA | No | 47 | |
rs10830963 | MTNR1B | 11 | G (0.30) | 5.8 × 10−175 | No | 47 | |
rs7944584 | MADD | 11 | A (0.75) | 2.0 × 10−18 | No | 47 | |
rs174550 | FADS1 | 11 | T (0.64) | 1.7 × 10−15 | No | 47 | |
rs11605924 | CRY2 | 11 | A (0.49) | 1.0 × 10−14 | No | 47 | |
rs231362 | KCNQ1 | 11 | G (0.52) | 2.8 × 10−13 | No | 52 | |
rs1552224 | CENTD2 | 11 | A (0.88) | 1.4 × 10−22 | No | 52 | |
rs1387153 | MTNR1B | 11 | T (0.28) | 7.8 × 10−15 | No | 52 | |
rs1531343 | HMGA2 | 12 | C (0.10) | 3.6 × 10−9 | No | 52 | |
rs7957197 | HNF1A | 12 | T (0.85) | 2.4 × 10−8 | No | 52 | |
rs11634397 | ZFAND6 | 15 | G (0.60) | 2.4 × 10−9 | No | 52 | |
rs11071657 | C2CD4B | 15 | A (0.63) | 3.6 × 10−8 | No | 47 | |
rs8042680 | PRC1 | 15 | A (0.22) | 2.4 × 10−10 | No | 52 | |
rs5945326 | DUSP9 | X | A (0.79) | 3.0 × 10−10 | No | 52 | |
Total cholesterol | |||||||
rs12027135 | LDLRAP1 | 1 | T (0.45) | 4 × 10−11 | Yes | 51 | |
rs7515577 | EVI5 | 1 | A (0.21) | 3 × 10−8 | No | 51 | |
rs2642442 | MOSC1 | 1 | T (0.32) | 6 × 10−13 | No | 51 | |
rs514230 | IRF2BP2 | 1 | T (0.48) | 5 × 10−14 | No | 51 | |
rs7570971 | RAB3GAP1 | 2 | C (0.34) | 2 × 10−8 | No | 51 | |
rs2290159 | RAF1 | 3 | G (0.22) | 4 × 10−9 | No | 51 | |
rs12916 | HMGCR | 5 | T (0.39) | 9 × 10−47 | No | 51 | |
rs6882076 | TIMD4 | 5 | C (0.35) | 7 × 10−28 | No | 51 | |
rs3177928 | HLA | 6 | G (0.16) | 4 × 10−19 | No | 51 | |
rs2814982 | C6orf106 | 6 | C (0.11) | 5 × 10−11 | No | 51 | |
rs9488822 | FRK | 6 | A (0.35) | 2 × 10−10 | No | 51 | |
rs12670798 | DNAH11 | 7 | T (0.23) | 9 × 10−10 | No | 51 | |
rs2072183 | NPC1L1 | 7 | G (0.25) | 3 × 10−11 | No | 51 | |
rs2081687 | CYP7A1 | 8 | C (0.35) | 2 × 10−8 | No | 51 | |
rs2737229 | TRPS1 | 8 | A (0.30) | 2 × 10−8 | No | 51 | |
rs2255141 | GPAM | 10 | G (0.30) | 2 × 10−10 | No | 51 | |
rs10128711 | SPTY2D1 | 11 | C (0.28) | 3 × 10−8 | No | 51 | |
rs7941030 | UBASH3B | 11 | C (0.38) | 2 × 10−10 | No | 51 | |
rs11065987 | BRAP | 12 | A (0.42) | 7 × 10−12 | No | 51 | |
rs1169288 | HNF1A | 12 | A (0.33) | 1 × 10−14 | No | 51 | |
rs2000999 | HPR | 16 | G (0.20) | 3 × 10−24 | No | 51 | |
rs4420638 | CILP2 | 19 | T (0.07) | 3 × 10−38 | No | 51 | |
rs492602 | FLJ36070 | 19 | A (0.49) | 2 × 10−10 | No | 51 | |
rs2277862 | ERGIC3 | 20 | C (0.15) | 4 × 10−10 | No | 51 | |
rs2902940 | MAFB | 20 | A (0.29) | 6 × 10−11 | No | 51 | |
Triglycerides | |||||||
rs2131925 | ANGPTL3 | 1 | T (0.32) | 9 × 10−43 | No | 51 | |
rs1042034 | APOB | 2 | T (0.22) | 1 × 10−45 | Yes | 51 | |
rs1260326 | GCKR | 2 | C (0.41) | 6 × 10−133 | No | 51 | |
rs10195252 | COBLL1 | 2 | T (0.40) | 2 × 10−10 | No | 51 | |
rs645040 | MSL2L1 | 3 | T (0.22) | 3 × 10−8 | No | 51 | |
rs442177 | KLHL8 | 4 | T (0.41) | 9 × 10−12 | No | 51 | |
rs9686661 | MAP3K1 | 5 | C (0.20) | 1 × 10−10 | No | 51 | |
rs2247056 | HLA | 6 | C (0.25) | 2 × 10−15 | No | 51 | |
rs13238203 | TYW1B | 7 | C (0.04) | 1 × 10−9 | No | 51 | |
rs17145738 | MLXIPL | 7 | C (0.12) | 6 × 10−58 | No | 51 | |
rs11776767 | PINX1 | 8 | G (0.37) | 1 × 10−8 | No | 51 | |
rs1495741 | NAT2 | 8 | A (0.22) | 5 × 10−14 | No | 51 | |
rs12678919 | LPL | 8 | A (0.12) | 2 × 10−115 | Yes | 51 | |
rs2954029 | TRIB1 | 8 | A (0.47) | 3 × 10−55 | Yes | 51 | |
rs10761731 | JMJD1C | 10 | A (0.43) | 3 × 10−12 | No | 51 | |
rs2068888 | CYP26A1 | 10 | G (0.46) | 2 × 10−8 | No | 51 | |
rs174546 | FADS1–2–3 | 11 | C (0.34) | 5 × 10−24 | No | 51 | |
rs964184 | APOA1 | 11 | C (0.13) | 7 × 10−240 | Yes | 51 | |
rs11613352 | LRP1 | 12 | C (0.23) | 4 × 10−10 | No | 51 | |
rs2412710 | CAPN3 | 15 | G (0.02) | 2 × 10−8 | No | 51 | |
rs2929282 | FRMD5 | 15 | A (0.05) | 2 × 10−11 | No | 51 | |
rs11649653 | CTF1 | 16 | C (0.40) | 3 × 10−8 | No | 51 | |
rs439401 | APOE | 19 | C (0.36) | 1 × 10−30 | No | 51 | |
rs5756931 | PLA2G6 | 22 | T (0.40) | 4 × 10−8 | No | 51 | |
Low-density lipoprotein | |||||||
rs2479409 | PCSK9 | 1 | A (0.23) | 2 × 10−28 | No | 51 | |
rs629301 | SORT1 | 1 | T (0.22) | 1 × 10−170 | Yes | 51 | |
rs1367117 | APOB | 2 | G (0.30) | 4 × 10−114 | Yes | 51 | |
rs499376 | ABCG5/8 | 2 | T (0.30) | 2 × 10−47 | Yes | 51 | |
rs3757354 | MYLIP | 6 | C (0.22) | 1 × 10−11 | No | 51 | |
rs1800562 | HFE | 6 | G (0.06) | 6 × 10−10 | No | 51 | |
rs1564348 | LPA | 6 | T (0.17) | 2 × 10−17 | Yes | 51 | |
rs11136341 | PLEC1 | 8 | A (0.40) | 4 × 10−13 | No | 51 | |
rs9411489 | ABO | 9 | C (0.20) | 6 × 10−13 | Yes | 51 | |
rs11220462 | ST3GAL4 | 11 | G (0.14) | 1 × 10−15 | No | 51 | |
rs8017377 | NYNRIN | 14 | G (0.47) | 5 × 10−11 | No | 51 | |
rs7206971 | OSBPL7 | 17 | G (0.49) | 2 × 10−8 | No | 51 | |
rs6511720 | LDLR | 19 | G (0.11) | 4 × 10−117 | Yes | 51 | |
rs4420638 | APOE | 19 | A (0.17) | 9 × 10−147 | No | 51 | |
rs6029526 | TOP1 | 20 | T (0.47) | 4 × 10−19 | No | 51 | |
High-density lipoprotein | |||||||
rs4660293 | PABPC4 | 1 | A (0.23) | 4 × 10−10 | No | 51 | |
rs1689800 | ZNF648 | 1 | A (0.35) | 3 × 10−10 | No | 51 | |
rs4846914 | GALNT2 | 1 | A (0.40) | 4 × 10−21 | No | 51 | |
rs2972146 | IRS1 | 2 | T (0.37) | 3 × 10−9 | No | 51 | |
rs12328675 | COBLL1 | 2 | T (0.13) | 3 × 10−10 | No | 51 | |
rs13107325 | SLC39A8 | 4 | C (0.07) | 7 × 10−11 | No | 51 | |
rs6450176 | ARL15 | 5 | G (0.26) | 5 × 10−8 | No | 51 | |
rs2814944 | C6orf106 | 6 | G (0.16) | 4 × 10−9 | No | 51 | |
rs605066 | CITED2 | 6 | T (0.42) | 3 × 10−8 | No | 51 | |
rs1084651 | LPA | 6 | G (0.16) | 3 × 10−8 | Yes | 51 | |
rs2293889 | TRPS1 | 8 | G (0.41) | 6 × 10−11 | No | 51 | |
rs4731702 | KLF14 | 7 | C (0.48) | 1 × 10−15 | No | 51 | |
rs9987289 | PPP1R3B | 8 | G (0.09) | 6 × 10−25 | No | 51 | |
rs581080 | TTC39B | 9 | C (0.18) | 3 × 10−12 | No | 51 | |
rs1883025 | ABCA1 | 9 | C (0.25) | 2 × 10−33 | No | 51 | |
rs2923084 | AMPD3 | 11 | A (0.17) | 5 × 10−8 | No | 51 | |
rs3136441 | LRP4 | 11 | T (0.15) | 3 × 10−18 | No | 51 | |
rs7134594 | PDE3A | 12 | C (0.42) | 4 × 10−8 | No | 51 | |
rs7134594 | MVK | 12 | T (0.47) | 7 × 10−15 | No | 51 | |
rs4759375 | SBNO1 | 12 | C (0.06) | 7 × 10−9 | No | 51 | |
rs4765127 | ZNF664 | 12 | G (0.34) | 3 × 10−10 | No | 51 | |
rs838880 | SCARB1 | 12 | T (0.31) | 3 × 10−14 | No | 51 | |
rs1532085 | LIPC | 15 | G (0.39) | 3 × 10−96 | No | 51 | |
rs2652834 | LACTB | 15 | G (0.20) | 9 × 10−9 | No | 51 | |
rs3764261 | CETP | 16 | C (0.32) | 7 × 10−380 | No | 51 | |
rs16942887 | LCAT | 16 | G (0.12) | 8 × 10−33 | No | 51 | |
rs2925979 | CMIP | 16 | C (0.30) | 2 × 10−11 | No | 51 | |
rs11869286 | STARD3 | 17 | C (0.34) | 1 × 10−13 | No | 51 | |
rs4148008 | ABCA8 | 17 | C (0.32) | 2 × 10−10 | No | 51 | |
rs4129767 | PGS1 | 17 | A (0.49) | 8 × 10−9 | No | 51 | |
rs7241918 | LIPG | 18 | T (0.17) | 3 × 10−49 | No | 51 | |
rs12967135 | MC4R | 18 | G (0.23) | 7 × 10−9 | No | 51 | |
rs7255436 | ANGPTL4 | 19 | A (0.47) | 3 × 10−8 | No | 51 | |
rs737337 | LOC55908 | 19 | T (0.08) | 3 × 10−9 | No | 51 | |
rs386000 | LILRA3 | 19 | G (0.20) | 4 × 10−19 | No | 51 | |
rs1800961 | HNF4A | 20 | C (0.03) | 1 × 10−15 | No | 51 | |
rs6065906 | PLTP | 20 | T (0.18) | 2 × 10−22 | No | 51 | |
rs181362 | UBE2L3 | 22 | C (0.20) | 1 × 10−8 | No | 51 | |
rsID | Loci | Chr | Risk allele (Risk allele frequency) |
P-value
|
Known effect On CAD | Reference | |
SBP | DBP | ||||||
| |||||||
Blood pressure | |||||||
rs2932538 | MOV10 | 1 | G (0.75) | 1.2 × 10−9 | 9.9 × 10−10 | No | 48 |
rs17367504 | MTHFR-NPPB | 1 | G (0.15) | 8.7 × 10−22 | 3.5 × 10−19 | No | 48 |
rs13002573 | FIGN | 2 | G (0.20) | 3.25 × 10−7 | 4.02 × 10−2 | No | 53 |
rs1446468 | FIGN | 2 | T (0.53) | 1.82 × 10−12 | 6.88 × 10−9 | No | 53 |
rs319690 | MAP4 | 3 | T (0.51) | 4.74 × 10−8 | 1.84 × 10−8 | No | 53 |
rs13082711 | SLC4A7 | 3 | T (0.78) | 1.5 × 10−6 | 3.8 × 10−9 | No | 48 |
rs419076 | MECOM | 3 | T (0.47) | 1.80 × 10−13 | 2.1 × 10−12 | No | 48 |
rs3774372 | ULK4 | 3 | T (0.83) | 0.39 | 9.0 × 10−14 | No | 48 |
rs871606 | CHIC2 | 4 | T (0.86) | 3.04 × 10−4 | 8.85 × 10−1 | No | 53 |
rs13107325 | SLC39A8 | 4 | T (0.05) | 3.3 × 10−14 | 2.3 × 10−17 | No | 48 |
rs13139571 | GUCY1A3-GUCY1B3 | 4 | C (0.76) | 1.2 × 10−6 | 2.2 × 10−10 | Yes | 48 |
rs1458038 | FGF5 | 4 | T (0.29) | 1.5 × 10−23 | 8.5 × 10−25 | No | 48 |
rs1173771 | NPR3-C5orf23 | 5 | G (0.60) | 1.8 × 10−16 | 9.1 × 10−12 | No | 48 |
rs11953630 | EBF1 | 5 | T (0.37) | 3.0 × 10−11 | 3.8 × 10−13 | No | 48 |
rs1799945 | HFE | 6 | G (0.14) | 7.7 × 10−12 | 1.5 × 10−15 | No | 48 |
rs805303 | BAT2-BAT5 | 6 | G (0.61) | 1.5 × 10−11 | 4.4 × 10−10 | No | 48 |
rs17477177 | PIK3CG | 7 | T (0.72) | 5.67 × 10−11 | 1.40 × 10−1 | No | 53 |
rs2071518 | NOV | 8 | T (0.17) | 2.08 × 10−2 | 3.89 × 10−3 | No | 53 |
rs2782980 | ADRB1 | 10 | T (0.20) | 7.66 × 10−7 | 9.60 × 10−8 | No | 53 |
rs4373814 | CACNB2 | 10 | G (0.55) | 4.8 × 10−11 | 4.4 × 10−10 | No | 48 |
rs932764 | PLCE1 | 10 | G (0.44) | 7.1 × 10−16 | 8.1 × 10−7 | No | 48 |
rs1813353 | CACNB2 | 10 | T (0.68) | 2.6 × 10−12 | 2.3 × 10−15 | No | 48 |
rs4590817 | C10orf107 | 10 | G (0.84) | 4.0 × 10−12 | 1.3 × 10−12 | No | 48 |
rs11191548 | CYP17A1-NT5C2 | 10 | T (0.91) | 6.9 × 10−26 | 9.4 × 10−13 | Yes | 48 |
rs11222084 | ADAMTS8 | 11 | T (0.38) | 4.00 × 10−4 | 3.44 × 10−2 | No | 53 |
rs7129220 | ADM | 11 | G (0.89) | 3.0 × 10−12 | 6.4 × 10−8 | No | 48 |
rs633185 | FLJ32810-TMEM133 | 11 | G (0.28) | 1.2 × 10−17 | 2.0 × 10−15 | No | 48 |
rs381815 | PLEKHA7 | 11 | T (0.26) | 5.3 × 10−11 | 5.3 × 10−10 | No | 48 |
rs17249754 | ATP2B1 | 12 | G (0.84) | 1.8 × 10−18 | 1.2 × 10−14 | No | 48 |
rs3184504 | SH2B3 | 12 | T (0.47) | 3.8 × 10−18 | 3.6 × 10−25 | Yes | 48 |
rs10850411 | TBX5-TBX3 | 12 | T (0.70) | 5.4 × 10−8 | 5.4 × 10−10 | No | 48 |
rs2521501 | FURIN-FES | 15 | T (0.31) | 5.2 × 10−19 | 1.9 × 10−15 | Yes | 48 |
rs1378942 | CYP1A1-ULK3 | 15 | C (0.35) | 5.7 × 10−23 | 2.7 × 10−26 | No | 48 |
rs17608766 | GOSR2 | 17 | T (0.86) | 1.1 × 10−10 | 0.017 | No | 48 |
rs12940887 | ZNF652 | 17 | T (0.38) | 1.8 × 10−10 | 2.3 × 10−14 | No | 48 |
rs1327235 | JAG1 | 20 | G (0.46) | 1.9 × 10−8 | 1.4 × 10−15 | No | 48 |
rs6015450 | GNAS-EDN3 | 20 | G (0.12) | 3.9 × 10−23 | 5.6 × 10−23 | No | 48 |
Abbreviations: Chr, chromosome; CAD, coronary artery disease; SBP, systolic blood pressure; DBP, diastolic blood pressure.