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. 2014 Jan 16;7:15–32. doi: 10.2147/TACG.S35301

Table 4.

Summary of main findings of most recent meta-analyses of genome-wide association studies of cardiovascular risk factors, showing the lead single nucleotide polymorphism of each locus, the closest gene, chromosomal location, risk allele and frequency, and P-value of the reported associations

rsID Loci Chr Risk allele (Risk allele frequency) Combined P-value Known effect on CAD Reference
Obesity
 rs2815752 NEGR1 1 A (0.61) 1.61 × 10−22 No 50
 rs543874 SEC16B 1 G (0.19) 3.56 × 10−23 No 50
 rs1514175 TNNI3K 1 A (0.43) 8.16 × 10−14 No 50
 rs1555543 PTBP2 1 C (0.59) 3.68 × 10−10 No 50
 rs984222 TBX15-WARS2 1 G (0.64) 3.81 × 10−14 No 49
 rs2867125 TMEM18 2 C (0.83) 2.77 × 10−49 No 50
 rs713586 RBJ 2 C (0.47) 6.17 × 10−22 No 50
 rs887912 FANCL 2 T (0.29) 1.79 × 10−12 No 50
 rs10195252 GRB14 2 T (0.60) 2.09 × 10−24 No 49
 rs13078807 LRP1B 2 C (0.18) 1.35 × 10−10 No 50
 rs9816226 ETV5 3 T (0.82) 1.69 × 10−18 No 50
 rs13078807 CADM2 3 G (0.20) 3.94 × 10−11 No 50
 rs6795735 ADAMTS9 3 C (0.60) 9.79 × 10−14 No 49
 rs6784615 NISCH-STAB1 3 T (0.94) 3.84 × 10−10 No 49
 rs13107325 SLC39A8 4 T (0.07) 1.50 × 10−13 No 50
 rs10938397 GNPDA2 4 G (0.43) 3.78 × 10−31 No 50
 rs2112347 FLJ35779 5 T (0.63) 2.17 × 10−13 No 50
 rs4836133 ZNF608 5 A (0.48) 1.97 × 10−9 No 50
 rs681681 CPEB4 5 A (0.34) 1.91 × 10−9 No 49
 rs987237 TFAP2B 6 G (0.18) 2.90 × 10−20 No 50
 rs206936 NUDT3 6 G (0.21) 3.02 × 10−8 No 50
 rs9491696 RSPO3 6 G (0.48) 1.84 × 10−40 No 49
 rs6905288 VEGFA 6 A (0.56) 5.88 × 10−25 No 49
 rs1294421 LY86 6 G (0.61) 1.75 × 10−17 No 49
 rs1055144 NFE2L3 7 T (0.21) 9.97 × 10−18 No 49
 rs10968576 LRRN6C 9 G (0.31) 2.65 × 10−13 No 50
 rs10767664 BNF 11 A (0.78) 4.69 × 10−26 No 50
 rs3817334 MTCH2 11 T (0.40) 1.59 × 10−12 No 50
 rs4929949 RPL27A 11 C (0.52) 2.80 × 10−9 No 50
 rs7138803 FAIM2 12 A (0.38) 1.82 × 10−17 No 50
 rs718314 ITPR2-SSPN 12 G (0.26) 1.14 × 10−17 No 50
 rs1443512 HOXC13 12 A (0.24) 6.38 × 10−17 No 49
 rs4771122 MTIF3 13 G (0.24) 9.48 × 10−10 No 50
 rs10150332 NRXN3 14 C (0.21) 2.75 × 10−11 No 50
 rs11847697 PRKD1 14 T (0.04) 5.76 × 10−11 No 50
 rs2241423 MAP2K5 15 G (0.78) 1.19 × 10−18 No 50
 rs1558902 FTO 16 A (0.42) 4.8 × 10−120 No 50
 rs7359397 SH2B1 16 T (0.40) 1.88 × 10−20 No 50
 rs12444979 GPRC5B 16 C (0.87) 2.91 × 10−21 No 50
 rs571312 MC4R 18 A (0.24) 6.43 × 10−42 No 50
 rs29941 KCTD15 19 G (0.67) 3.01 × 10−9 No 50
 rs2287019 QPCTL 19 C (0.80) 1.88 × 10−16 No 50
 rs3810291 TMEM160 19 A (0.67) 1.64 × 10−12 No 50
 rs4823006 ZNRF3-KREMEN1 22 A (0.57) 1.10 × 10−11 No 49
Diabetes
 rs340874 PROX1 1 C (0.52) 6.6 × 10−12 No 47
 rs560887 G6PC2 2 C (0.70) 8.7 × 10−218 No 47
 rs780094 GCKR 2 C (0.62) 5.6 × 10−38 No 47
 rs243021 BCL11A 2 A (0.46) 2.9 × 10−15 No 52
 rs7578326 IRS1 2 A (0.64) 5.4 × 10−20 No 52
 rs11708067 ADCY5 3 A (0.78) 7.1 × 10−22 No 47
 rs11920090 SLC2A2 3 T (0.87) 8.1 × 10−13 No 47
 rs4457053 ZBED3 5 G (0.26) 2.8 × 10−12 No 52
 rs4607517 GCK 7 A (0.16) 6.5 × 10−92 No 47
 rs2191349 DGKB-TMEM195 7 T (0.52) 3.0 × 10−44 No 47
 rs972283 KLF14 7 G (0.55) 2.2 × 10−10 No 52
 rs11558471 SLC30A8 8 A (0.68) NA No 47
 rs896854 TP53INP1 8 T (0.48) 9.9 × 10−10 No 52
 rs7034200 GLIS3 9 A (0.49) 1.0 × 10−12 No 47
 rs13292136 CHCHD9 9 C (0.93) 2.8 × 10−8 No 52
 rs10885122 ADRA2A 10 G (0.87) 2.9 × 10−16 No 47
 rs4506565 TCF7L2 10 T (0.31) NA No 47
 rs10830963 MTNR1B 11 G (0.30) 5.8 × 10−175 No 47
 rs7944584 MADD 11 A (0.75) 2.0 × 10−18 No 47
 rs174550 FADS1 11 T (0.64) 1.7 × 10−15 No 47
 rs11605924 CRY2 11 A (0.49) 1.0 × 10−14 No 47
 rs231362 KCNQ1 11 G (0.52) 2.8 × 10−13 No 52
 rs1552224 CENTD2 11 A (0.88) 1.4 × 10−22 No 52
 rs1387153 MTNR1B 11 T (0.28) 7.8 × 10−15 No 52
 rs1531343 HMGA2 12 C (0.10) 3.6 × 10−9 No 52
 rs7957197 HNF1A 12 T (0.85) 2.4 × 10−8 No 52
 rs11634397 ZFAND6 15 G (0.60) 2.4 × 10−9 No 52
 rs11071657 C2CD4B 15 A (0.63) 3.6 × 10−8 No 47
 rs8042680 PRC1 15 A (0.22) 2.4 × 10−10 No 52
 rs5945326 DUSP9 X A (0.79) 3.0 × 10−10 No 52
Total cholesterol
 rs12027135 LDLRAP1 1 T (0.45) 4 × 10−11 Yes 51
 rs7515577 EVI5 1 A (0.21) 3 × 10−8 No 51
 rs2642442 MOSC1 1 T (0.32) 6 × 10−13 No 51
 rs514230 IRF2BP2 1 T (0.48) 5 × 10−14 No 51
 rs7570971 RAB3GAP1 2 C (0.34) 2 × 10−8 No 51
 rs2290159 RAF1 3 G (0.22) 4 × 10−9 No 51
 rs12916 HMGCR 5 T (0.39) 9 × 10−47 No 51
 rs6882076 TIMD4 5 C (0.35) 7 × 10−28 No 51
 rs3177928 HLA 6 G (0.16) 4 × 10−19 No 51
 rs2814982 C6orf106 6 C (0.11) 5 × 10−11 No 51
 rs9488822 FRK 6 A (0.35) 2 × 10−10 No 51
 rs12670798 DNAH11 7 T (0.23) 9 × 10−10 No 51
 rs2072183 NPC1L1 7 G (0.25) 3 × 10−11 No 51
 rs2081687 CYP7A1 8 C (0.35) 2 × 10−8 No 51
 rs2737229 TRPS1 8 A (0.30) 2 × 10−8 No 51
 rs2255141 GPAM 10 G (0.30) 2 × 10−10 No 51
 rs10128711 SPTY2D1 11 C (0.28) 3 × 10−8 No 51
 rs7941030 UBASH3B 11 C (0.38) 2 × 10−10 No 51
 rs11065987 BRAP 12 A (0.42) 7 × 10−12 No 51
 rs1169288 HNF1A 12 A (0.33) 1 × 10−14 No 51
 rs2000999 HPR 16 G (0.20) 3 × 10−24 No 51
 rs4420638 CILP2 19 T (0.07) 3 × 10−38 No 51
 rs492602 FLJ36070 19 A (0.49) 2 × 10−10 No 51
 rs2277862 ERGIC3 20 C (0.15) 4 × 10−10 No 51
 rs2902940 MAFB 20 A (0.29) 6 × 10−11 No 51
Triglycerides
 rs2131925 ANGPTL3 1 T (0.32) 9 × 10−43 No 51
 rs1042034 APOB 2 T (0.22) 1 × 10−45 Yes 51
 rs1260326 GCKR 2 C (0.41) 6 × 10−133 No 51
 rs10195252 COBLL1 2 T (0.40) 2 × 10−10 No 51
 rs645040 MSL2L1 3 T (0.22) 3 × 10−8 No 51
 rs442177 KLHL8 4 T (0.41) 9 × 10−12 No 51
 rs9686661 MAP3K1 5 C (0.20) 1 × 10−10 No 51
 rs2247056 HLA 6 C (0.25) 2 × 10−15 No 51
 rs13238203 TYW1B 7 C (0.04) 1 × 10−9 No 51
 rs17145738 MLXIPL 7 C (0.12) 6 × 10−58 No 51
 rs11776767 PINX1 8 G (0.37) 1 × 10−8 No 51
 rs1495741 NAT2 8 A (0.22) 5 × 10−14 No 51
 rs12678919 LPL 8 A (0.12) 2 × 10−115 Yes 51
 rs2954029 TRIB1 8 A (0.47) 3 × 10−55 Yes 51
 rs10761731 JMJD1C 10 A (0.43) 3 × 10−12 No 51
 rs2068888 CYP26A1 10 G (0.46) 2 × 10−8 No 51
 rs174546 FADS1–2–3 11 C (0.34) 5 × 10−24 No 51
 rs964184 APOA1 11 C (0.13) 7 × 10−240 Yes 51
 rs11613352 LRP1 12 C (0.23) 4 × 10−10 No 51
 rs2412710 CAPN3 15 G (0.02) 2 × 10−8 No 51
 rs2929282 FRMD5 15 A (0.05) 2 × 10−11 No 51
 rs11649653 CTF1 16 C (0.40) 3 × 10−8 No 51
 rs439401 APOE 19 C (0.36) 1 × 10−30 No 51
 rs5756931 PLA2G6 22 T (0.40) 4 × 10−8 No 51
Low-density lipoprotein
 rs2479409 PCSK9 1 A (0.23) 2 × 10−28 No 51
 rs629301 SORT1 1 T (0.22) 1 × 10−170 Yes 51
 rs1367117 APOB 2 G (0.30) 4 × 10−114 Yes 51
 rs499376 ABCG5/8 2 T (0.30) 2 × 10−47 Yes 51
 rs3757354 MYLIP 6 C (0.22) 1 × 10−11 No 51
 rs1800562 HFE 6 G (0.06) 6 × 10−10 No 51
 rs1564348 LPA 6 T (0.17) 2 × 10−17 Yes 51
 rs11136341 PLEC1 8 A (0.40) 4 × 10−13 No 51
 rs9411489 ABO 9 C (0.20) 6 × 10−13 Yes 51
 rs11220462 ST3GAL4 11 G (0.14) 1 × 10−15 No 51
 rs8017377 NYNRIN 14 G (0.47) 5 × 10−11 No 51
 rs7206971 OSBPL7 17 G (0.49) 2 × 10−8 No 51
 rs6511720 LDLR 19 G (0.11) 4 × 10−117 Yes 51
 rs4420638 APOE 19 A (0.17) 9 × 10−147 No 51
 rs6029526 TOP1 20 T (0.47) 4 × 10−19 No 51
High-density lipoprotein
 rs4660293 PABPC4 1 A (0.23) 4 × 10−10 No 51
 rs1689800 ZNF648 1 A (0.35) 3 × 10−10 No 51
 rs4846914 GALNT2 1 A (0.40) 4 × 10−21 No 51
 rs2972146 IRS1 2 T (0.37) 3 × 10−9 No 51
 rs12328675 COBLL1 2 T (0.13) 3 × 10−10 No 51
 rs13107325 SLC39A8 4 C (0.07) 7 × 10−11 No 51
 rs6450176 ARL15 5 G (0.26) 5 × 10−8 No 51
 rs2814944 C6orf106 6 G (0.16) 4 × 10−9 No 51
 rs605066 CITED2 6 T (0.42) 3 × 10−8 No 51
 rs1084651 LPA 6 G (0.16) 3 × 10−8 Yes 51
 rs2293889 TRPS1 8 G (0.41) 6 × 10−11 No 51
 rs4731702 KLF14 7 C (0.48) 1 × 10−15 No 51
 rs9987289 PPP1R3B 8 G (0.09) 6 × 10−25 No 51
 rs581080 TTC39B 9 C (0.18) 3 × 10−12 No 51
 rs1883025 ABCA1 9 C (0.25) 2 × 10−33 No 51
 rs2923084 AMPD3 11 A (0.17) 5 × 10−8 No 51
 rs3136441 LRP4 11 T (0.15) 3 × 10−18 No 51
 rs7134594 PDE3A 12 C (0.42) 4 × 10−8 No 51
 rs7134594 MVK 12 T (0.47) 7 × 10−15 No 51
 rs4759375 SBNO1 12 C (0.06) 7 × 10−9 No 51
 rs4765127 ZNF664 12 G (0.34) 3 × 10−10 No 51
 rs838880 SCARB1 12 T (0.31) 3 × 10−14 No 51
 rs1532085 LIPC 15 G (0.39) 3 × 10−96 No 51
 rs2652834 LACTB 15 G (0.20) 9 × 10−9 No 51
 rs3764261 CETP 16 C (0.32) 7 × 10−380 No 51
 rs16942887 LCAT 16 G (0.12) 8 × 10−33 No 51
 rs2925979 CMIP 16 C (0.30) 2 × 10−11 No 51
 rs11869286 STARD3 17 C (0.34) 1 × 10−13 No 51
 rs4148008 ABCA8 17 C (0.32) 2 × 10−10 No 51
 rs4129767 PGS1 17 A (0.49) 8 × 10−9 No 51
 rs7241918 LIPG 18 T (0.17) 3 × 10−49 No 51
 rs12967135 MC4R 18 G (0.23) 7 × 10−9 No 51
 rs7255436 ANGPTL4 19 A (0.47) 3 × 10−8 No 51
 rs737337 LOC55908 19 T (0.08) 3 × 10−9 No 51
 rs386000 LILRA3 19 G (0.20) 4 × 10−19 No 51
 rs1800961 HNF4A 20 C (0.03) 1 × 10−15 No 51
 rs6065906 PLTP 20 T (0.18) 2 × 10−22 No 51
 rs181362 UBE2L3 22 C (0.20) 1 × 10−8 No 51
rsID Loci Chr Risk allele (Risk allele frequency) P-value
Known effect On CAD Reference
SBP DBP
Blood pressure
 rs2932538 MOV10 1 G (0.75) 1.2 × 10−9 9.9 × 10−10 No 48
 rs17367504 MTHFR-NPPB 1 G (0.15) 8.7 × 10−22 3.5 × 10−19 No 48
 rs13002573 FIGN 2 G (0.20) 3.25 × 10−7 4.02 × 10−2 No 53
 rs1446468 FIGN 2 T (0.53) 1.82 × 10−12 6.88 × 10−9 No 53
 rs319690 MAP4 3 T (0.51) 4.74 × 10−8 1.84 × 10−8 No 53
 rs13082711 SLC4A7 3 T (0.78) 1.5 × 10−6 3.8 × 10−9 No 48
 rs419076 MECOM 3 T (0.47) 1.80 × 10−13 2.1 × 10−12 No 48
 rs3774372 ULK4 3 T (0.83) 0.39 9.0 × 10−14 No 48
 rs871606 CHIC2 4 T (0.86) 3.04 × 10−4 8.85 × 10−1 No 53
 rs13107325 SLC39A8 4 T (0.05) 3.3 × 10−14 2.3 × 10−17 No 48
 rs13139571 GUCY1A3-GUCY1B3 4 C (0.76) 1.2 × 10−6 2.2 × 10−10 Yes 48
 rs1458038 FGF5 4 T (0.29) 1.5 × 10−23 8.5 × 10−25 No 48
 rs1173771 NPR3-C5orf23 5 G (0.60) 1.8 × 10−16 9.1 × 10−12 No 48
 rs11953630 EBF1 5 T (0.37) 3.0 × 10−11 3.8 × 10−13 No 48
 rs1799945 HFE 6 G (0.14) 7.7 × 10−12 1.5 × 10−15 No 48
 rs805303 BAT2-BAT5 6 G (0.61) 1.5 × 10−11 4.4 × 10−10 No 48
 rs17477177 PIK3CG 7 T (0.72) 5.67 × 10−11 1.40 × 10−1 No 53
 rs2071518 NOV 8 T (0.17) 2.08 × 10−2 3.89 × 10−3 No 53
 rs2782980 ADRB1 10 T (0.20) 7.66 × 10−7 9.60 × 10−8 No 53
 rs4373814 CACNB2 10 G (0.55) 4.8 × 10−11 4.4 × 10−10 No 48
 rs932764 PLCE1 10 G (0.44) 7.1 × 10−16 8.1 × 10−7 No 48
 rs1813353 CACNB2 10 T (0.68) 2.6 × 10−12 2.3 × 10−15 No 48
 rs4590817 C10orf107 10 G (0.84) 4.0 × 10−12 1.3 × 10−12 No 48
 rs11191548 CYP17A1-NT5C2 10 T (0.91) 6.9 × 10−26 9.4 × 10−13 Yes 48
 rs11222084 ADAMTS8 11 T (0.38) 4.00 × 10−4 3.44 × 10−2 No 53
 rs7129220 ADM 11 G (0.89) 3.0 × 10−12 6.4 × 10−8 No 48
 rs633185 FLJ32810-TMEM133 11 G (0.28) 1.2 × 10−17 2.0 × 10−15 No 48
 rs381815 PLEKHA7 11 T (0.26) 5.3 × 10−11 5.3 × 10−10 No 48
 rs17249754 ATP2B1 12 G (0.84) 1.8 × 10−18 1.2 × 10−14 No 48
 rs3184504 SH2B3 12 T (0.47) 3.8 × 10−18 3.6 × 10−25 Yes 48
 rs10850411 TBX5-TBX3 12 T (0.70) 5.4 × 10−8 5.4 × 10−10 No 48
 rs2521501 FURIN-FES 15 T (0.31) 5.2 × 10−19 1.9 × 10−15 Yes 48
 rs1378942 CYP1A1-ULK3 15 C (0.35) 5.7 × 10−23 2.7 × 10−26 No 48
 rs17608766 GOSR2 17 T (0.86) 1.1 × 10−10 0.017 No 48
 rs12940887 ZNF652 17 T (0.38) 1.8 × 10−10 2.3 × 10−14 No 48
 rs1327235 JAG1 20 G (0.46) 1.9 × 10−8 1.4 × 10−15 No 48
 rs6015450 GNAS-EDN3 20 G (0.12) 3.9 × 10−23 5.6 × 10−23 No 48

Abbreviations: Chr, chromosome; CAD, coronary artery disease; SBP, systolic blood pressure; DBP, diastolic blood pressure.