Table 2.

Selected examples of correlates of protection in NHP models

Correlates of protection from: --disease or high viral load (d) -- or acquisition (a)			Challenge virus/route/dose	Vaccine platforms	Reference
Cellular immune responses	CD8	general	SIVmac251	DNA/NYVAC	(Hel et al., 2002a)
		TCM	SIVmac251d	DNA/Poxvirus	(Vaccari et al., 2005)
		TEM	SIVmac259 intrarectala	Recombinant CMV	(Hansen et al., 2011)
		Polyfunctional T cell	SIVmac239d	Live attenuated SHIV89.6	(Genesca et al., 2012)
			SIVmac251d	Peptide/Poxvirus With adjuvant	(Sui et al., 2010)
			SHIV89.6Pd	DNA/Ad5/Poxvirus	(Sun et al., 2008)
		Avidity of T cell	SIVmac251d	DNA/MVA	(O’Connor et al., 2002)
		Mucosal high- avidity T cell (Rectal)	SHIVKUIId	Peptide/Poxvirus	(Belyakov et al., 2006)
		Public clonotype	SIVmac239d	DNA/Ad5	(Price et al., 2009b)
	CD4	general	SIVmac251	DNA/NYVAC	(Hel et al., 2002a)
		TCM	SIVmac251	DNA/MVA	(Vaccari et al., 2008)
		TEM	N/A	N/A	N/A
Humoral immune responses	Neutralization antibodies		HIV (chimpanzees) SHIVSF162P3a	passive immunization with antibody	(Emini et al., 1992) (Hessell et al., 2009)
	Binding antibodies		SHIV89.6P	Replicating Ad5/gp120	(Demberg et al., 2007)
	ADCC		SIVmac251	Replicating Ad5/gp120 boost	(Gomez- Roman et al., 2005)
	Avidity of the antibodies		SHIV89.6P	Replicating Ad5/gp120	(Xiao et al., 2010)
			SIVsmE660	DNA/MVA	(Lai et al., 2012)
			SHIV162.P3	DNA/MVA	(Zhao et al., 2009)
	Mucosal antibodies IgA		SIVmac251a	Replicating recombinant Ad5/gp120 boost	(Xiao et al., 2012)
Innate immunity	APOBEC3G		SIVmac251d	Peptide/MVA with adjuvant	(Sui et al., 2010)

N/A: Not Available

NB: This table was not meant to be comprehensive, but only to provide examples