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Mean cognitive function score (CFS) by treatment arm over time. Mid-treatment, doxorubicin–cyclophosphamide (AC): day 29; end of treatment, AC: 4–5 months. Mid-treatment, cyclophosphamide–methotrexate–5-fluorouracil (CMF): day 77; end of treatment, CMF: 6–7 months. Mid-treatment, capecitabine: day 63; end of treatment, capecitabine: 4–5 months. Error bars represent 95 % CI for the adjusted average cognitive function score (CFS)
