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. 2014 Feb 10;211(2):281–295. doi: 10.1084/jem.20131494

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© 2014 Hu et al.

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Figure 10. — 19,20-DHDP and DAPT rescue retinal angiogenesis in Fbxw7^iECKO mice. (A) Isolectin B4 staining of the retinal whole mounts (top; bars, 500 µm) and tip cells at the angiogenic front (bottom; bars, 50 µm) in P5 retinas from wild-type (WT) mice or Fbxw7^iECKO mice 5 h after intravitreal injection of 0.5 µl solvent, 100 µmol/liter 19,20-EDP, 100 µmol/liter 19,20-DHDP, or 200 µmol/liter DAPT. (B–D) The graphs summarize vessel branch points (B), tip cell (C), and filopodia numbers (D). n = 1–2 animals per group, and the experiment was independently performed 4 times. Error bars represent SEM. ***, P < 0.001 versus wild-type. §, P < 0.05; §§, P < 0.01; §§§, P < 0.001 versus Fbxw7^iECKO and solvent.