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A) NagZ catalyzed hydrolysis of peptidoglycan cell-wall fragments releases the series of 1,6-anhydroMurNAc peptide inducer molecules that activate transcription of ampC expression (tripeptide shown). B) The putative transition state of the NagZ catalyzed hydrolysis of N-acetylglucosaminides (denoted by ≠). C) Structures of known inhibitors of NagZ enzymes.
