Table 3.

Selective cardiovascular disease risk factors as a function of the rs20455 genotype and statin medication usage.

Risk factors	AA Trp/Trp n = 53  23%	AG Arg/Trp n = 120  51%	GG Arg/Arg n = 62  26%	ANOVA P value
Age
Total	52 ± 7	54 ± 7	52 ± 6.9	0.09
No statins	51 ± 10	52 ± 9	50 ± 10	0.28
Statins	52 ± 4	54 ± 6	52 ± 7
HDL-C
Total	60 ± 14	64 ± 15	61 ± 16	0.21
No statins	60 ± 16	65 ± 7	63 ± 15	0.06
Statins	56 ± 11	61 ± 15	52 ± 14
LDL-C
Total	114 ± 36	113 ± 38	113 ± 37	0.71
No statins	118 ± 39	119 ± 39	116 ± 34	0.59
Statins	106 ± 32	101 ± 36	113 ± 40
TG
Total	119 ± 58	109 ± 67	130 ± 741,2	0.009
No statins	118 ± 60	107 ± 74	111 ± 54
Statins	121 ± 50	113 ± 39	177 ± 973	0.002
Waist Circ
Total	37 ± 7	37 ± 6	36 ± 7
No statins	36 ± 6	37 ± 4	37 ± 4	0.93
Statins	37 ± 4	36 ± 7	37 ± 3
BMI
Total	26 ± 4	28 ± 4	26 ± 4	0.06
No statins	26 ± 4	27 ± 4	25 ± 5
Statins	30 ± 5	30 ± 4	27 ± 5	0.15
Hs-CRP
Total	1.41 ± 1.5	1.86 ± 2.2	1.55 ± 2.1	0.45
No statins	2.1 ± 3.9	2.2 ± 3.3	1.6 ± 1.7
Statins	1.6 ± 2.9	1.4 ± 1.9	2.2 ± 3.0	0.87
HbA1c
Total	5.8 ± 0.46	5.8 ± 0.49	6.01 ± 0.97	0.39
No statins	5.8 ± 0.48	5.8 ± 0.48	5.9 ± 0.66
Statins	6.3 ± 1.2	6.1 ± 0.54	6.4 ± 1.5	0.17

Note: HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein-cholesterol; TG: triglycerides; Waist Circ: waist circumference; BMI: body mass index; hs-CRP: high-sensitivity C-reactive protein; HbA1c: Hemoglobin A1c. ¹ P < 0.05 Trp/Trp versus Arg/Arg, ² P < 0.01 Arg/Trp versus Arg/Arg, and ³Arg/Arg versus all other groups P < 0.001; AA no statins n = 22, statins n = 12; AG no statins n = 48, statins n = 21; GG no statins n = 26, statins n = 16.