Table 7.
Statistical comparison of the proposed and published methods for determination of Irbesartan (IRB), Losartan potassium (LOS) and Telmisartan (TEL) in presence Hydrochlorothiazide (HCTZ) respectively in their dosage forms by reported method (T- student test) and (F –test for variance).
| Drug name | Recovery ± SD |
Calculated
t- values |
Calculated F- values | ||
|---|---|---|---|---|---|
| Proposed methods | Reference method | ||||
| X-tension plus tablets | IRB (%) | 99.26±0.76 | 98.98 ±1.10 | 1.36 | 0.48 |
| HCTZ (%) | 98.76 ±0.70 | 98.15 ±0.96 | 2.14 | 0.52 | |
| Losazide tablets | LOS (%) | 100.35±0.56 | 100.10±0.43 | 0.84 | 1.71 |
| HCTZ (%) | 99.47 ±0.50 | 99.97±0.55 | 1.15 | 0.84 | |
| Micardis plus tablets | TEL (%) | 99.51 ±0.20 | 99.70±0.287 | 2.19 | 0.50 |
| HCTZ (%) | 99.25 ±0.28 | 99.17±0.59 | 0.61 | 0.22 | |
(Where the Tabulated t-values and F -ratios at p = 0.05 are 2.57 and 5.05)