Figure 3.

Relationship between pancreatic β-cell area, as determined from pancreatic tissue removed at surgery, and the C-peptide–to–glucose ratio determined in the fasting state (A) and 30 min after oral glucose ingestion in 8 individuals with normal glucose tolerance (NGT), 14 with impaired fasting glucose (IFG) or impaired glucose tolerance (IGT), and 11 with diabetes. r and P values were calculated by linear regression analysis. These analyses demonstrate the tight relationship between β-cell mass and β-cell function. Modified from ref. 75.