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. 2014 Jan 23;2014:129048. doi: 10.1155/2014/129048

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Copyright © 2014 Sebastian Gehmert et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Relative quantification of MyoD mRNA is shown as mean ± SD percentage of MyoD mRNA expression in murine myoblasts after 72 h myostatin treatment. Myostatin exposure significantly reduced MyoD mRNA to 22.8% (±4.6%, **P < 0.001) in comparison to untreated myoblasts. Due to the effect of conditioned medium from wild type ASCs MyoD, mRNA significantly increased to 51.2% (±5.9%, **P < 0.001) when compared to myostatin treatment. But this effect was accountable for IGF-1 by 87.3% since IGF-1 depleted CM decreased MyoD mRNA level to 26.4% (±3.4%, n.s. compared to myostatin treatment) (N = 3, n = 3).