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. Author manuscript; available in PMC: 2014 Mar 10.
Published in final edited form as: J Control Release. 2012 Nov 12;166(2):124–129. doi: 10.1016/j.jconrel.2012.11.004

Figure 3. HB-EGF coacervate accelerates healing of full-thickness excisional wounds.

Figure 3

(a) Silicone donut-shaped splints, fixed with suture, surrounded the wounds and forced healing to occur by re-epithelialization. Wounds were treated immediately with 10 μl of group-specific solution by sterile pipet. (b) Wound closure over time, measured as percent of original area. Fourteen wounds were averaged for day 7 timepoint after which two animals were sacrificed per group for histology; the remaining 10 wounds per group were photographed until sacrifice on day 17. Bars indicate means ± SD. *P<0.05; **P<0.01. (c) Representative photographs of wounds treated with saline, vehicle (PEAD:heparin complex), 1 μg HB-EGF free or in the coacervate. Ruler units are mm.