Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Oct 17;4(10):e860. doi: 10.1038/cddis.2013.391

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2013 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/

PMC Copyright notice

Electron microscopy findings 3 weeks after IOP elevation. Laminar portion in the control (a) and experimental glaucoma (b) groups. Abnormal mitochondria (black arrowheads) and autophagic vacuoles (black arrows) were noted in unmyelinated axons in experimental glaucoma (b). Myelinated portion in the experimental glaucoma (c and d), glaucoma+Nmnat3 transfection (e and f), and glaucoma+rapamycin (g and h) groups. Degenerative changes such as neurofilament accumulation (white asterisk) were noted in experimental glaucoma (c). The formation of multilamellar bodies is characteristic of autophagic vacuoles (white arrows; c an d). Preserved myelin and microtubule structures were noted in glaucoma+Nmnat3 transfection (e and f) and glaucoma+rapamycin (g and h) groups. A phagophore was observed in the glaucoma+Nmnat3 transfection (black asterisk; e) group. Autophagic vacuoles (white arrowheads) were observed in the glaucoma (d), glaucoma+Nmnat3 transfection (f), and glaucoma+rapamycin (g and h) groups. Scale bar=1 μm (a and b) and 200 nm (c–h)