Table 1.
Demographics, and Clinical Characteristics of Study Participants (N = 79)
| Variable | HA (n= 40) | HCV+ High CR (n= 19) | HCV+ Low CR (n= 20) | p | Group comparisons |
|---|---|---|---|---|---|
| Demographics | |||||
| Age (years) | 47.9 (13.4) | 54.5 (7.7) | 50.6 (7.9) | .12 | |
| Ethnicity (% Caucasian) | 70.0 | 79.0 | 75.0 | .75 | |
| Sex (% Male) | 72.5 | 57.9 | 95.0 | .01 | HCV low CR > HA, HCV high CR |
| Cognitive Reserve | |||||
| Education (years) | 13.8 (2.3) | 15.1 (1.7) | 12.6 (1.5) | .001 | HCV high CR > HCV low CR |
| RIST (Index Score) | 107.6 (11.1) | 108.7 (7.8) | 95.7 (7.6) | < .0001 | HCV low CR < HCV high CR, HA |
| WTAR (Standard Score) | 106.8 (12.4) | 109.7 (7.5) | 94.4 (12.7) | < .0001 | HCV low CR < HCV high CR, HA |
| CR score (z-score) | .15 (.80) | .45 (.53) | .73 (.46) | < .0001 | HCV low CR < HCV high CR, HA |
| Psychiatric | |||||
| BDI-II | 4.5 (5.1) | 6.4 (6.9) | 8.5 (7.6) | .07 | |
| Substance Use Disorder (% Lifetime) | 35.0 | 73.7 | 80.0 | .0006 | HA < HCV high CR, HCV low CR |
| Liver Biomarkers | |||||
| AST | 22.8 (6.7) | 59.2 (42.9) | 52.4 (41.6) | < .0001 | HCV high CR, HCV low CR > HA |
| ALT | 25.1 (13.6) | 77.1 (47.1) | 79.5 (62.3) | < .0001 | HCV high CR, HCV low CR > HA |
| APRI | .25 (.13) | .88 (.98) | .72 (.94) | .002 | HCV high, CR HCV low CR > HA |
| Ammonia | 42.8 (17.4) | 38.6 (13.3) | 44.9 (18.7) | .57 | |
| Bilirubin | .48 (.20) | .53 (.22) | .50 (.31) | .76 | |
| Albumin | 4.4 (.32) | 4.2 (.26) | 4.3 (.40) | .04 | HA > HCV high CR |
Note: HA = Healthy Adults; HCV = Hepatitis C virus; CR = Cognitive Reserve; RIST = Reynolds Intelligence Screening Test; WTAR = Wechsler Test of Adult Reading; BDI-II = Beck Depression Inventory-II; AST = Aspartate aminotransferase; ALT = Alanine Aminotransferase; APRI = Aspartate aminotransferase-to-Platelet Ration Index.