. Author manuscript; available in PMC: 2014 Aug 15.

Published in final edited form as: J Immunol. 2014 Jan 15;192(4):1862–1869. doi: 10.4049/jimmunol.1302147

Table I.

Compilation of published and our own data on anti-human selectin monoclonal antibodies binding the N-terminal lectin domain and their relation of target epitopes to relevant conformational switch regions as defined by (19) (Figure 6A). Known binding sites and differential ligand interactions are indicated as previously published. I = inhibitory, S = stimulatory, NF = non-functional, nd = not determined

				Action
mAb-clone	Selectin	Epitope residues	Switch	I	S	NF	Ligand	Sources
EP-5C7, 1.2B6, BBIG-E6	E/P	21, 22, 23, 119, 120		X			sLe^x	(44, 45)
C215	P	76 - 83	S3			X	sLe^x	(46)
C215	P	76 - 83	S3	X			PSGL-1	(46)
TQ-1	L/E	nd		X			PPME	(16)
TQ-1	L/E	nd				X	HEV	(16)
LAM1-1	L	nd			X		PPME	(16, 26), this report
LAM1-1	L	nd		X			HEV, PSGL-1	(16, 26), this report
LAM1-7, 8, 9, 10, 11, 12, 13	L	nd				X	PPME	(16, 26)
LAM1-7, 8, 9, 10, 11, 12, 13	L	nd				X	HEV	(16, 26)
LAM1-5	L	nd			X		PPME, PSGL-1	(16), this report
LAM1-5	L	nd				X	HEV	(16), this report
LAM1-6	L	nd				X	PPME	(16, 26)
LAM1-6	L	nd		X			HEV	(16, 26)
LAM1-108, 110, 115, 116, 120	L	nd		X			HEV	(33)
LAM1-108, 110, 115, 116, 120	L	nd			X		Intercellular	(33)
DREG-55	L	11, 56, 87, 89, 105, 107, 111	S1, 3		X		PSGL-1, E-selectin	(30, 41), this report
				X			HEV, PNAd, sLe^x
					(X)		PPME
DREG-56	L	nd		X			PPME, HEV, PSGL-1	(41), this report
DREG-200	L	45, 46, 47		X			PSGL-1, E-selectin PNAd, sLe^x	(30, 41), this report
						X	PPME
				(X)			HEV