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. 2014 Feb 11;9(2):e83871. doi: 10.1371/journal.pone.0083871

Figure 10. Age related changes in retinal function and morphology of GHL+ and GHL+/Ask1−/− mice.

Figure 10

(A) b/a wave ratio in C57BL/6, Ask1−/−, GHL+, and GHL+/Ask1−/− mice. (B) Representative sections of retinas from 16 week old C57BL/6, Ask1−/−, GHL+ and GHL+/Ask1−/− mice. GHL+ and GHL+/Ask1−/− retinas had shortened OS (arrowheads). (C) Mean number of photoreceptor nuclei per column counted in the ONL. Error bars: ± SD. OPL: outer plexiform layer, ONL: outer nuclear layer, OS: outer segment. Scale bar 50 µm. (D) The variance in the number of photoreceptor nuclei per column counted in different zones of the retina in GHL+ and GHL+/Ask1−/− mice, (right panel). Superior zone: 630 µm from the CMZ, central zone: 630 µm from optic nerve, and inferior zone: midpoint of inferior hemisphere.