Table 5. Cox multivariate model for long-term mortality from randomization.

Variable	Comparator	Hazard Ratio (95% CI)	p-Value
Age (by quartiles)	<56 years (index)
	56–67 years	1.39 (1.14–1.70)	0.001
	67–76 years	1.52 (1.24–1.85)	<0.001
	>76 years	1.85 (1.53–2.25)	<0.001
Study treatment	Higher vs lower dose	1.07 (0.94–1.22)	0.32
APACHE III score	10 unit increase	1.12 (1.09–1.15)	<0.001
Randomization serum creatinine	44 µmol/l increase	0.96 (0.94–0.97)	<0.001