Figure 10. The p38 MAPK-specific inhibitor SB203580 inhibited NO and TNF-α production by suppressing NF-κB and AP-1 activities.

(A) BV2 cells were treated with LPS for 16 h in the absence or presence of SB203580, and released NO and TNF-α were measured as previously described. Bars indicate the mean ± S.E.M. of three independent experiments. *P<0.05; significantly different from LPS-treated cells. SB indicates SB203580. (B) Effect of SB203580 on LPS-induced NF-κB and AP-1 DNA binding activities.