Figure 2.

Genes upregulated approaching rejection are highly neutrophil enriched while genes downregulated are highly lymphocyte enriched. A. Comparison of gene enrichment scores (Benita et al³⁶) for genes that are upregulated approaching rejection in neutrophils and monocyte CD14+ versus peripheral CD4+ and CD8+ T cells. These genes are highly enriched in neutrophils and monocytes compared to peripheral T cells. A positive score indicates enrichment and negative score indicates absence. B. Comparison of gene enrichment scores for genes that are downregulated approaching rejection in neutrophils and monocytes versus peripheral CD4+ and CD8+ T cells indicates these genes are highly enriched in T lymphocytes. C and D. Sum of enrichment scores for various blood cell and different tissue types shows that upregulated genes represent a neutrophil signature (C) and that downregulated genes represent a T lymphocyte signature (D).