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. 2014 Feb 11;9(2):e88587. doi: 10.1371/journal.pone.0088587

Figure 4. Synergistic effect of the FAK and BCL2/BCL-XL inhibitors in triggering cell death.

Figure 4

A, Cell proliferation assays were performed 72-737 (□: A), BEZ235 (○: B), PF271 (△: P), ABT-737 combined with 1 µM BEZ235 (▪: AB), ABT-737 combined with 5 µM PF271 (•: AP), and ABT-737 combined with 1 µM BEZ235 and 5 µM PF271 (▴: ABP) for 72 hr. Cell viability (%) was calculated and dose response curves were predicted with a four-parameter log-logistic function. B, OVMANA, RMGI, TOV21G, and OVISE cells were exposed to ABT-737 (0.2 or 1 µM), BEZ235 (0.2 or 1 µM), or PF271 (1, or 5 µM) individually or in combinations for 24 hr. The values of cytotoxicity (%) indicate the percentage of dead cells for each treatment. The cytotoxicity data represented in B are the means ± SD from a single representative of three experiments. A synergistic effect was observed when the cells were treated with both ABT-737 and PF271.