Table 4. Regression models for oxytocin receptor (OXTR) methylation across participating women.
Model | CpG 1 | CpG 34 | CpG 35 | CpG 46 | CpG 47 | |||||
R2 | 0.648 | 0.646 | 0.522 | 0.221 | 0.288 | |||||
P | <0.001 | <0.001 | <0.001 | 0.198 | 0.063 | |||||
Factors | Beta | p | Beta | p | Beta | p | Beta | p | Beta | p |
Age | 0.124 | 0.259 | 0.021 | 0.850 | −0.019 | 0.882 | 0.064 | 0.695 | −0.151 | 0.334 |
BMI | −0.756*** | <0.001 | −0.845*** | <0.001 | −0.575*** | <0.001 | −0.327 | 0.098 | −0.469* | 0.015 |
EDE-Q global | 0.436** | 0.002 | 0.368** | 0.008 | 0.234 | 0.134 | 0.244 | 0.219 | 0.188 | 0.320 |
AQ total | 0.039 | 0.743 | −0.072 | 0.548 | 0.156 | 0.266 | 0.051 | 0.774 | 0.082 | 0.629 |
BDI | −0.120 | 0.563 | 0.015 | 0.943 | −0.054 | 0.825 | 0.219 | 0.479 | −0.184 | 0.534 |
STAI_State | −0.376 | 0.057 | −0.803*** | <0.001 | −0.161 | 0.476 | −0.184 | 0.523 | 0.169 | 0.539 |
STAI_Trait | 0.324 | 0.132 | 0.553* | 0.013 | 0.331 | 0.186 | −0.099 | 0.754 | 0.102 | 0.735 |
BMI, body mass index; AN, anorexia nervosa; EDE-Q, Eating Disorder Examination Questionnaire; AQ, Autism-Spectrum Quotient; BDI, Beck Depression Inventory; STAI, Spielberger State and the Trait Anxiety Inventory.
* p<0.05, ** p<0.01, *** p<0.001.