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. 2014 Feb 11;9(2):e88591. doi: 10.1371/journal.pone.0088591

Figure 1. Cross-sectional analysis of CSF NFL in HIV disease.

Figure 1

Included were 14 subjects diagnosed with HIV-associated dementia (HAD); HIV positive neuroasymptomatic subjects (NA) without antiretroviral treatment stratified according to levels of blood CD4 T-cells <50 (n = 42), 50–199 (n = 49), 200–349 (n = 52) and >350 (n = 57); 85 subjects on combination antiretroviral treatment (ART) for at least one year and plasma HIV-RNA <50 copies/ml and 204 HIV seronegative volunteers (HIV-neg). CSF NFL concentrations were higher in patients with HAD compared to all other groups. Elevated levels of CSF NFL was also found in subjects with a CD4+ T-cell count below 50 cells/mL compared to groups in higher CD4+ T-cell count strata. Whiskers represent full range