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. 2014 Feb 11;9(2):e88591. doi: 10.1371/journal.pone.0088591

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© 2014 Jessen Krut et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Overall CSF NFL levels decreased in 63% of the patients after initiation of cART (p<0.01), demonstrated as a lower CSF NFL geometric mean (dotted line) after initiation of cART. 33% of the patents had elevated levels of CSF NFL at baseline and 81% of those exhibited reduction in their CSF NFL levels after treatment (p<0.01). 35% of patients with pathological CSF NFL at baseline normalized their levels (green colored). Those with normal CSF NFL at baseline exhibited no significant reduction in CSF NFL (blue colored). Three patients with normal baseline CSF NFL exhibited elevated levels of CSF NFL after cART initiation (red colored).