(A) Scattergram of EM66 concentrations in plasma samples of healthy volunteers (controls, ×, n = 21), and patients with pheochromocytoma before surgical removal of the tumor (preop, +, n = 37). (B) Distribution of EM66 preoperative concentrations of patients reported in (A), depending on the adrenal (PHEO, ▴, n = 26) or extra-adrenal (PGL, ▾, n = 11) location of the tumor, the benign (•, n = 32) or malignant (▪, n = 5), and the sporadic (♦, n = 24) or hereditary (•, n = 13) nature of the neoplasm. The grey zone corresponds to the distribution of control values and indicates the cut-off level for EM66 test assay. See legends of Figure 2 for other designations.