Table 1. WE-14 plasma concentrations in healthy volunteers and patients with pheochromocytoma.
| WE-14 (ng/ml) | Sensitivity (%) | ||||||||||
| Median | Minimal value | Maximal value | WE-14 | CgA | EM66 | WE-14 +CgA | WE-14 +EM66 | CgA +EM66 | WE-14 +CgA+EM66 | ||
| Controls | (n = 21) | 0.689 | 0.525 | 2.106 | - | - | - | - | - | - | - |
| Patients | (n = 37) | 3.695*** | 0.494 | 61.027 | 83.8 | 83.8 | 83.8 | 91.9 | 91.9 | 89,2 | 94,6 |
| Postoperative | (n = 12) | 1.154 | 0.382 | 1.997 | - | - | - | - | - | - | - |
| Pheochromocytoma | (n = 26) | 3.204*** | 0.896 | 61.027 | 80,8 | 84,6 | 80,8 | 92,3 | 88,5 | 88,5 | 92,3 |
| Paraganglioma | (n = 11) | 5.484*** | 0.494 | 47.245 | 90,9 | 81,8 | 90,9 | 90,9 | 100 | 90,9 | 100 |
| Benign | (n = 32) | 3.776*** | 0.494 | 47.245 | 84,4 | 84,4 | 90,6 | 90,6 | 93,8 | 90,6 | 93,8 |
| Malignant | (n = 5) | 3.078* | 1.345 | 61.027 | 80 | 80 | 40 | 100 | 80 | 80 | 100 |
| Sporadic | (n = 24) | 4.224*** | 1.303 | 61.027 | 91,7 | 95,8 | 87,5 | 100 | 95,8 | 95,8 | 100 |
| Hereditary | (n = 13) | 2.542* | 0.494 | 19.354 | 69,2 | 61,5 | 76,9 | 76,9 | 84,6 | 76,9 | 84,6 |
Comparison of the diagnostic sensitivity of WE-14, CgA and EM66 assays.
*, median value of controls vs median value of patients, pheochromocytoma, paraganglioma, benign, malignant, sporadic or hereditary tumors. * p<0.05, *** p<0.001; n, number of individuals.