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. 2014 Feb 11;9(2):e88703. doi: 10.1371/journal.pone.0088703

Figure 1. Scheme of biosynthetic pathways for major nervous system gangliosides.

Figure 1

Blockades in ganglioside biosynthesis in knockout mice are indicated by solid red lines. GM2/GD2-synthase knockout mice (B4galnt1-null) mice do not express any complex gangliosides, including GM1, GD1a, GD1b or GT1b, and express only simple gangliosides GM3 and GD3. GD3-Synthase knockout mice (St8sia1-null), which lack the GD3 synthase required for synthesis of b-series gangliosides, overexpress a-series gangliosides (highlighted), particularly GM1 and GD1a, and do not express b-series gangliosides GD3, GD2, GD1b, and GT1b.