Table 1. Transgenic/mutant mice used in the studies.
Strain name | Strain description |
Fcer1g-null | lack all activating but express inhibitory FcγRIIB |
Fcer1α-null | lack activating FcγRI only but express all other FcγRs |
Fcgr2b-null | Lack inhibitory FcγRIIB but express all activating FcγRs |
Fcgr3-null | lack activating FcγRIII only but express all other FcγRs |
Fcgr4-null | lack activating FcγRIV only but express all other FcγRs |
Osteopetrotic mice | mutant mice (op/op), devoid of colony stimulating factor 1, are macrophage and microglia deficient |
C3-null | lack complement component C3 |
B4galnt1-null | express only simple gangliosides GM3 and GD3, but not complex gangliosides GM1, GD1a, GD1b or GT1b [50] |
St8sia1-null | over-expresses a-series gangliosides, particularly GM1 and GD1a and do not express b-series gangliosides GD3, GD2, GD1b, and GT1b [51] |
FcγRs = Fcγ receptors.