Fig. 3.

Effect of MC3/4R antagonism in young female SHR. Young female SHR (aged 4 mos) were implanted with intracerebroventricular (icv) cannulas and radiotelemeters, as described in materials and methods. Two weeks later, baseline MAP and heart rate were measured for 5 days, and rats were given SHU-9119 (1 nmol/h at 0.5 μl/h icv; n = 11) or vehicle (icv 0.9% NaCl; n = 5) for 9 days. A: food intake during the baseline period and during SHU-9119 infusion. Data are presented as grams per day and expressed as means ± SE. *P < 0.05 compared with vehicle-treated rats. B: MAP in young females during baseline and SHU-9119 (or vehicle) infusion. Data are presented as mmHg and expressed as means ± SE. C: heart rate in young females during baseline and SHU-9119 (or vehicle) infusion. Data are presented as beats per minute (bpm) and expressed as means ± SE. *P < 0.05 in SHU-9119 treated rats compared with baseline period.