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. 2013 Dec 31;306(4):R248–R256. doi: 10.1152/ajpregu.00490.2013

Fig. 5.

Fig. 5.

Effect of MC3/4R antagonism in old male SHR. Old male SHR, aged 18–20 mo (n = 6) were implanted with intracerebroventricular cannulas and radiotelemeters, as described in materials and methods. Two weeks later, baseline MAP and heart rate were measured for 5 days, and then SHU-9119 (1 nmol/h at 0.5 μl/h icv) was given for 9 days. A: food intake during the baseline period and during SHU-9119 infusion. Data are presented as grams per day and expressed as means ± SE. *P < 0.05 SHU-9119 treatment compared with baseline. B: MAP in old males during baseline and SHU-9119 infusion. Data are presented as mmHg and expressed as means ± SE. *P < 0.05 SHU-9119 treatment compared with baseline. C: heart rate in old males during baseline and SHU-9119 infusion. Data are presented as bpm and expressed as means ± SE. *P < 0.05 in SHU-9119-treated rats compared with baseline period.