Table 2.

Changes in body weight and percentage change in body weight in rats before and after blockade with SHU-9119 (or vehicle)

	Baseline Body weight, g	After Treatment Body weight, g (% change)
Young
Female control	214.3 ± 5.9	232.2 ± 7.5* (+8.3 ± 1.8%)*
Young females + SHU-9119	209.3 ± 8.4	269.3 ± 12.5*† (+28.8 ± 3.8%)*†
Old
Female control	228 ± 9	220 ± 10
Female + SHU-9119	217 ± 11	257 ± 6*§ (18 ± 2)*†¶
Male + SHU-9119	356 ± 27	438 ± 9* (23 ± 3‡

Values are means ± SE; n, 6 rats for all groups.

^*P < 0.01 compared with baseline of same sex.

^†P < 0.01 compared with placebo of same sex during SHU infusion;

^‡P < 0.05 compared with young or old females in placebo or SHU infusion.