Table 2.

miRNAs that express aberrantly in human psoriatic skin and relative amount of their companion 5′-isomiRs

miRNA	Description	Fold Change (PP/NN)	IsomiRs, %
miR-31	regulates cytokine/chemokine expression via targeting serine/threonine kinase 40 (STK40)	42.9	0.4
miR-977	mirtron; upregulated in psoriatic skin	6.4	1.3
miR-135b/miR-7	targets late cornified envelope-1B (LCE1B); impairs barrier development and response to environmental stimuli	5.6/3.1	0.4/1.0
miR-1983	tRNA-derived human homolog of murine miR-1983	4.9	0.2
miR-21	contributes to T cell-derived psoriatic skin inflammation	4.0	0.6
miR-203-AS	antisense to miR-203	2.7	7
miR-155/miR-142/miR-146a	cell fate decisions in hematopoietic development	2.7/2.5/2.3	1.1/46/0.8
miR-223	suppresses cell proliferation by targeting IGF-1R	2.5	9.8
miR-203	regulates the transition from basal to suprabasal layer in epidermis	1.6	43
miR-205	primarily in the basal layer expressed in normal skin and regulates the transcriptional repressor of E-cadherin to maintain epithelial-mesenchymal transition	1.6	0.5
miR-99a/miR-100	inhibits angiogenesis by repressing the mammalian target of rapamycin (mTOR) in endothelial cells	−2.1/−2.3	3.1/0.7
mir-10a	regulates the behavior of endothelial cells during angiogenesis	−2.3	22
miR-124	downregulation in skin cancer, cutaneous squamous cells	−5.9	23
miR-4490	novel miRNA from intergenic region	−8.1	1.2

Fold change is a value of miRNA expression in psoriatic skin (PP) divided by that in normal skin (NN). IsomiRs, the percentage of reads mapping to miRNA hairpins identified as 5′-isomiRs.