Fig. 6.

Working model for regulation of blood flow rate after WBF loading. The data presented here are summarized in this proposed model. Blood flow rate is immediately increased and maintained at the site of bone formation in the 2 wk after WBF loading. Elevated blood flow rate is initially facilitated by vasodilation and then maintained at the site of bone formation through angiogenesis as inflammation subsides. Inhibition of either vasodilation or angiogenesis impairs the woven bone formation response. The regulation of angiogenesis in the context of woven bone remodeling from days 7 to 14 and beyond is not well understood.